Regression analysis of mean quality-adjusted lifetime with censored data
نویسندگان
چکیده
منابع مشابه
Regression analysis of mean quality-adjusted lifetime with censored data.
In clinical trials of chronic diseases such as acquired immunodeficiency syndrome, cancer, or cardiovascular diseases, the concept of quality-adjusted lifetime (QAL) has received more and more attention. In this paper, we consider the problem of how the covariates affect the mean QAL when the data are subject to right censoring. We allow a very general form for the mean model as a function of c...
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In the clinical trials of chronic diseases such as cancer or AIDS, it has been increasingly recognized that it is not enough just to consider simple time to event end points. For example, a new experimental drug may prolong overall survival time of patients, but in the meantime, it can be toxic for a longer period of time. Therefore, the trade-off between the quality and quantity of life of pat...
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The authors consider the empirical likelihood method for the regression model of mean qualityadjusted lifetime with right censoring. They show that an empirical log-likelihood ratio for the vector of the regression parameters is asymptotically a weighted sum of independent chi-square distributions. They obtain an adjusted empirical log-likelihood ratio which is asymptotically standard chi-squar...
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Zhao and Tsiatis (1997) consider the problem of estimation of the distribution of the quality-adjusted lifetime when the chronological survival time is subject to right censoring. The quality-adjusted lifetime is typically defined as a weighted sum of the times spent in certain states up until death or some other failure time. They propose an estimator and establish the relevant asymptotics und...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2006
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxl016